HISTOPATHOLOGY of Rattusattus norvegicus KIDNEY INFECTED by Leptospira = GAMBARAN HISTOPATOLOGI GINJAL Rattus norvegicus INFEKTIF LEPTOSPIRA

Arief Mulyono, Ristiyanto Ristiyanto, Farida Dwi Handayani, Noor Soesanti H

HISTOPATHOLOGY of Rattusattus norvegicus KIDNEY INFECTED by Leptospira = GAMBARAN HISTOPATOLOGI GINJAL Rattus norvegicus INFEKTIF LEPTOSPIRA

Abstract


ENGLISH

Abstract

A study on the histological structure of Rattus norvegicus kidney infected by Leptospira has been conducted. The purpose of this study was to determine the change of kidney tissue structure of R. norvegicus due to the patogenicity of Leptospira bacteria. The study was done in Miroto, Central Semarang District, Semarang Municipality. Rattus norvegicus was caught with live trap. The blood and kidney specimen were taken from all the caught rat. Then the blood was serologically examined by using Leptotek Dri-Dot, whereas the kidney was histopatologically observed under the microscope by using Hematoxylin-Eosin staining. The data were collected qualitatively and then analyzed descriptively by describing histological kidney appearance of R. norvegicus which were infected by Leptospira. The results of this research showed that 11 individuals of R. norvegicus caught and 8 induvidual infected by Leptospira. The results of R. norvegicus histological kidney examination which were infected by Leptospira show capillaries dilatation and hyalinization in glomerulus.

INDONESIAN

Telah dilakukan penelitian tentang struktur histopalogi organ ginjal tikus got (Rattus norvegicus) terinfeksi Leptospira. Tujuan penelitian untuk mengetahui perubahan struktur jaringan ginjal R. norvegicus akibat patogenitas bakteri Leptospira. Penelitian dilakukan di kelurahan Miroto, Kecamatan Semarang Tengah, Kota Semarang. Rattus norvegicus ditangkap dengan perangkap dan tikus tertangkap diambil spesimen darah dan ginjal. Darah diperiksa secara serologis dengan Leptotek Dri-Dot. Sedangkan ginjal diperiksa secara histopatologis dengan pewarnaan Haemotoxylin-Eosin dan diperiksa di bawah mikroskop. Jumlah R. norvegicus yang tertangkap dan diperiksa sebanyak 11 ekor. Pemeriksaan serologi menunjukkan R. norvegicus infektif Leptospira sebanyak 8 ekor. Hasil pemeriksaan histopatologis ginjal R. norvegicus terinfeksi Leptospira, menunjukkan terjadinya perubahan struktur berupa dilatasi kapiler dan hialinisasi pada glomerulus.


Keywords


Kidney, Histophatology, Rattus norvegicus, Leptospirosis, Ginjal, Histopatologi, Leptospirosis

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Jurnal Kefarmasian Indonesia


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p-ISSN: 2085-675X

e-ISSN: 2354-8770

Jurnal Kefarmasian Indonesia is a scientific journal published by the Center for Research and Development of Biomedical and Basic Health Technology, Board of Health Research and Development, Ministry of Health of the Republic of Indonesia. The journal publishes original research articles in pharmaceutical science such as Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care.

The journal was established in 2009 while online publication has been started from 2015. The journal is published in Bahasa Indonesia and English.  Jurnal Kefarmasian Indonesia is biannual, open access, peer-reviewed, and online pharmacy journal. Jurnal Kefarmasian Indonesia aims to serve the updated scientific knowledge for researchers in pharmaceutical fields. There is no charge for submitted manuscript as well as for processing manuscript. The journal has been registered with e-ISSN 2354-8770, and p-ISSN 2085-675X and accredited by Indonesian Institute of Sciences (LIPI) with Decree No. 581/Akred/P2MI/LIPI/09/2014.

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