Esti Rahardianingtyas.



Leptospirosis is a disease caused by bacterial infection leptospira interrogans.
Leptospira bacteria is a spiral bacterium with solid strands with two flagella periplasmik.
Septicaemic phase patient samples taken from the blood and cerebrospinal fluid, whereas
samples taken at phase immune extracted from urine. The diagnosis of leptospirosis occur
directly or indirectly. Diagnosis is done by directly isolate and identify the causative agents of
the agent. Diagnosis is done indirectly by detecting specific antibodies from the patient's body.
Gold Standard of the diagnosis of leptospirosis is MAT. Mat made by reacting antibodies to
leptospira antigen. Positive results seen with clump formed.
Key words: Leptospirosis, Leptospirosis Diagnostic, MAT (Microscopic Agglutination Test


Leptospirosis merupakan penyakit yang disebabkan karena infeksi bakteri leptospira
interrogans. Bakteri leptospira merupakan bakteri spiral dengan untaian yang padat dengan dua
flagella periplasmik. Sampel pasien pada fase septicaemic diambil dari darah dan cairan
serebrospinal, sedangkan sampel yang diambil pada fase immune diambil dari urine. Diagnosis
leptospirosis dilakukan secara langsung maupun tidak langsung. Diagnosis secara langsung
dilakukan dengan cara mengisolasi agen penyebab dan mengidentifikasi agen tersebut. Diagnosis
secara tidak langsung dilakukan dengan cara mendeteksi antibodi spesiflk dari dalam tubuh
pasien. Gold Standart dari diagnosis leptospirosis adalah MAT. Mat dilakukan dengan cara
mereaksikan antibodi dengan antigen leptospira. Hasil positif dilihat dengan terbentuk gumpalan
Kata kunci: Leptospirosis, Leptospira, Leptospirosis Diagnosis.

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