Review Artikel : Respon Antibodi terhadap Protein Permukaan Merozoit Plasmodium Falciparum dalam Penentuan Transmisi Malaria

Anis Nurwidayati

Review Artikel : Respon Antibodi terhadap Protein Permukaan Merozoit Plasmodium Falciparum dalam Penentuan Transmisi Malaria

Abstract


Malaria is one of the issues most important public health around the world. Malaria is the leading cause of death and disease in developing countries, children and pregnant women are the group most vulnerable to infection. Transmission measurements made as the evaluation of malaria control programs. Some epidemiological models ofmalaria that has been develope is useful in describing the transmission of malaria is based on several factors.

In this review described briefly regarding the transmission of malaria, measurement methods, especially measurement serologically transmission, serological markers used, as well as anti-malarial antibody response that appears on these serological markers.

There are three main methods of measuring the transmission of malaria, namely Entomological Inoculation Rates (EIR),Vectorial Capacity (VC) and Case Basic Reproduction Rate (Ro). malaria transmission measurement can also be done by using serological markers. Serological marker that has been proven can be used to estimate the malaria transmission for long periods or being in the endemic areas is the MSP-1, MSP-2, and AMA-1.

Antibody responses may reflect the occurrence of malaria transmission due to higher antibody responses correlated positively with exposure to Plasmodium infection. Serological parameters has advantages over other measurement methods to determine the endemicity, because the antibody response can persist for several months to severalyears after infection.


Keywords


antibody anti merozoit; malarial transmission; serological marker; Plasmodium falciparum

References


Branch H O, Venkatchala U, Allen W H, Aggrey J O, William A H et a|.

A Longitudinal Investigation of IgG and IgM Antibody Responses to

the Merozoite Surface Protein-l 19 Kilodalton Domain of Plasmodium

falciparum in Pregnant Women and Infants : Association with Febrile Illnes, Parasitemia, and Anemia. American Journal of Tropical Medicine and Hygiene. 1998; 58(2): 211-219.

Corran Patrick, Paul Coleman, Eleanor Riley and Chris Drakeley. Serology : a robust indicator of malaria transmission intensity?. TRENDS in Parasitology. 2007; 30(10). www. sciencedirect.com. Diakses pada: 21 Agustus 2010, 8:06:49AM.

Drakeley,C.J, PH Corran, P.G Coleman, J.E Tongren, S.L.R. McDonald, et al. Estimating Medium and Long Term Trends in Malaria Transmission by Using Serological Markers of Malaria Exposure. PNAS Journal. 2005; 102 (14): 5108-5113. diakses pada : 3 Agustus 2010,3: 13 :33 PM.

Fowkes FJI, Richards JS, SimpsonJA, Beeson JG. 2010. The Relationship between Anti-merozoite Antibodies and Incidence of Plasmodium falciparum Malaria: A Systematic Review and Meta-analysis. PLoS Med; Vol 7(1): e1000218 DOI: 1 0. 1371/journal.pmed. 1000218. http://www.plosmedicine.org. Diakses pada: 3 Agustus 2010,2:58:23PM

Haas, Marilyn and Susannah Fulling. Plasmodium falciparum Membrane Antigen 1 (AMAI). http.//biology.kenyon.edu/BMB/Chime2/

/AMA1/index.htm.2006. Diakses pada : 31 Agustus 2010; 15.50.

Holder AA. Proteins on the surface of the malaria parasite and cell invasion. Division of Parasitology, National Institute for Medical Research, London, UK. Parasitology. 1994; 108 Suppl:5-18.

Holder AA, Blackman MJ, Burghaus PA, Chappel JA, Ling IT, McCallum-Deighton N, Shai S. A malaria merozoite surface protein (MSPl)-structure, processing and function. National Institute for Medical

Research, Division of Parasitology, London, U.K.1994.

Omosun YO, Anumudu CI, Adoro S, Odaibo AB, Sodeinde O, Holder AA, Nwagwu M, Nwuba RI. 2005. Variation in the relationship between anti-MSP-1(19) antibody response and age in children infected with Plasmodium falciparum during the dry and rainy seasons. Department of Zoology, University of Ibadan, Ibadan, Nigeria. Acta TroP. 2005; 95(3): 233-47. http://www.ncbi.nlm.nih.gov/pubmed/16055071. Diakses pada : 1 Juli 2010. 9:25:35 PM.

Perraut R, Puijalon OM. Diouf B, Tall A, Guillotte M, et al, 2000. Seasonal Fluctuation of Antibod Levels to Plasmodium falciparum Parasitized Red Blood Cell-Associated Antigen in Two Senegalese Villages with Different Transmission Conditions. American Journal of TroPical Medicine and Hygiene. 2000; 62 (6): 746-751 . http://http://www.ncbi.nlm.

Qari, S.H., et al. Predicted and Observed Alleles of Plasmodium

falciparum Merozoite Surface Protein-1 (MSP-1), a Potential Malaria Vacoine Antigen. Molecular and Biochemical Parasitology. 1998; 92: 241 -252.h@://www.brown.edu/ Courses/Bio_160/Projects 1999/malaria/antgs.html.Diakses pada 30 Juli 2010,7:28.45 AM

Steward Laveta, Roly Gosling, Jamie Griffin, samwel Gesase, Joseph Campo, Ramadhan Hashim, et al. Rapid Assesment of Malaria Transmission Using Age-Spesific Sero-Conversion Rates. PlosOne. 2009;4. Issue 6.

Supargiyono, Satoto TT, Wijayanti MA, Buwono DT. Malaria Prevalence and Incidence at Purworejo Cental Java-Indonesia. Laporan Penelitian Proyek MTC Indonesia.2009.

Torres JK, Clark EH, Hemandez JN, Cornejo K E S, Dionicia Gamboa and Branch O H.2008. Antibody response dynamics to the Plasmodium falciparum conserved vaccine candidate antigen, merozoite surface protein-1 C-terminal 19kD (MSPI- 19kD), in Peruvians exposed to hypoendemic malaria transmission. Malaria Journal. 2008. http://www.malariajournal.corn/content/7/1/173. Diakses pada 11 Agustus 2010, 10:52:56 AM.

Wipasa J, Suphavilai C, Okell LC, Cook J, Corran PH. 2010. Long Lived Antibody and B Cell Memory Responses to the Human Malaria Parasites, Plasmodium falciparum and Plasmodium vivax. PLoS Pathog

; 6(2): e1000770.doi:10.13711 journal.ppat.1000770.http://www.plospathogens.org.Diakses pada

: 21 Agustus 2010, 8:06:49AM.

WHO. About malaria. http://www.cdc.gov/malaria/.2010.Diakses pada : 24 Juni 2010, 4:52:27 PM

WHO. Geographic distribution and statitistic. http://www.cdc.gov/malaria/malaria_worldwide/impact.html. 2010. http://wwwnc.cdc.gov/travel/yellowbook/2010/chapter-2/malaria-risk-information-and-prophylaxis.aspx


Full Text: PDF

Refbacks

  • There are currently no refbacks.


Jurnal Vektor Penyakit (p-issn: 1978-3647, e-issn: 2354-8835) is published by Balai Penelitian dan Pengembangan Pengendalian Penyakit Bersumber Binatang Donggala.
Indexing:


Visitor:

web
analytics
View My Stats
Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International LicenseArticles in the Jurnal Vektor Penyakit are Open Access articles under a Creative Commons Attribution-ShareAlike 4.0 International license (CC BY-SA 4.0). These license permits use, distribution and reproduction in any medium, provided the original work is properly cited and initial publication in this journal. In addition to that, users must provide a link to the license, indicate if changes are made and distribute using the same license as original if the original content has been remixed, transformed or built upon.