FORMULATION OF LIQUORICE ROOT EXTRACT (Glycyrrhiza glabra L.) AS SKIN WHITENING CREAM

Siti Umrah Noor, Faridah faridah, Michico michico

Abstract


ABSTRACT

Liquorice root extract (Glycyrrhiza glabra L.) contains glabridin, an isoflavane as inhibitors of tyrosinase. This enzyme is responsible in melanin synthesis. The aim of this research was to determine the tyrosinase inhibition activity of liquorice root extract and to formulate into a cream with a variety of emulsifier agent glyceryl monostearate. Liquorice root was macerated using ethanol 96%, invitro tyrosinase inhibition assay was conducted using kojic acid as positive control in 96-well plate. The physical quality parameters of the cream were also evaluated. The results showed that liquorice root extract inhibits tyrosinase with the IC50 126.75 µg/mL. Creams containing 1.01% liquorice root extract were yellowish white, aromatics odour, soft texture, homogen and no segregation in O/W emulsion type. It also showed plastic thixotropic rheological property, viscosity of (2800±0.00) – (4000±0.00) Ps, spreadability of (3029.72±0.81) – (3531.79±6.15)mm2, droplet size of (60.00±0.00) – (65.12±0.01)μm, pH of (4.55±0.03)–(4.63±0.04) and inhibited tyrosinase 10.14 - 19.30%. It can be concluded that the formula with 0.1% of glyceryl monostearate was the best formula that conforms physical quality test and potentially to be developed as a skin whitening cream.


Keywords


liquorice root extract, glyceryl monostearate, tyrosinase inhibitor, skin whitening cream

References


REFERENCES

Batubara I, Darusman LK, Mitsunaga T,

Rahminiwati M and Djauhari E. 2010.

Potency of Indonesian medicinal plants

as tyrosinase inhibitor and antioxidant

agent. J. Bio. Sci. 10(2): 138-144.

Damle M. 2014. Glycyrrhiza glabra

(Liquorice)-a potent medicinal herb. Int J

Herb Med. 2(2 Part C):132–6.

Yamauchi K, Mitsunaga T, Batubara I. 2011.

Isolation, Identification and Tyrosinase

Inhibitory Activities of the Extractives

from Allamanda cathartica. Nat Resour.

(03):167–72.

Yokota T, Nishio H, Kubota, Mizoguchi M.

The inhibitory effect of Glabridin

from Licorice Extracts on Melanogenesis.

Pigment Cell Res.; 11:955-96


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Jurnal Tumbuhan Obat Indonesia (Journal of  Indonesian Medicinal Plant, p-ISSN : 1979-892X, e-ISSN : 2354-8797) is published by Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional (B2P2TOOT) Tawangmangu.

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