ANTIARTHRITIS ACTIVITY OF COMBINATION OF RED GINGER (Zingiber officinale Rosc.) AND ACALYPHA (Acalypha indica Linn) EXTRACTS ON ARTHTRITIS RAT Aktivitas Antiarthritis Kombinasi Ekstak Jahe Merah (Zingiber officinale Rosc.) dan Acalypha (Acalypha indica Li

Rina Herowati, Gunawan P Widodo, Ismi Puspitasari

ANTIARTHRITIS ACTIVITY OF COMBINATION OF RED GINGER (Zingiber officinale Rosc.) AND ACALYPHA (Acalypha indica Linn) EXTRACTS ON ARTHTRITIS RAT Aktivitas Antiarthritis Kombinasi Ekstak Jahe Merah (Zingiber officinale Rosc.) dan Acalypha (Acalypha indica Li

Abstract


 

ABSTRACTArthritis is a chronic inflammatory disease affecting the musculoskeletal system and caused by a multisystem autoimmune reaction. Some medicinal herbs work synergistically to reduce chronic joint inflammation in arthritis. The purpose of this study was to determine the antiarthtritis activity of combination of red ginger rhizome and acalypha whole plant ethanolic extracts on complete Freund’s adjuvant induced arthtritis. Adjuvant arthritis was induced in rats on day 0. Nine days after inoculation, the animals were selected and distributed into 5 groups. One group was given 0.5% CMC solution as vehicle-treated group, the others were given red ginger extract (280 mg/kg bw), acalypha extract (200 mg/kg bw) combination of red ginger and acalypha extracts (140 mg/kg bw:100 mg/kg bw), and triamcinolone (0.3 mg/kg bw) orally. The degree of inflammation was evaluated by hind paw sweeling, supported by histopathology of ankle joints. Results suggested that oral dosage of acalypha extract, red ginger extract, as well as their combination reduced hind paw swelling, comparable to that’s of triamcinolone. Histopathology study revealed the significant reduction in mononuclear infiltration and increased the ankle joint space. The combination of red ginger rhizome and acalypha extracts showed protective effect against adjuvant induced arthritis.Keywords: red ginger rhizome, acalypha, complete Freund’s adjuvant, antiarthritis, histopathology

 

ABSTRAK Arthritis adalah penyakit peradangan kronis yang mempengaruhi sistem muskuloskeletal dan disebabkan oleh reaksi autoimun multisistem. Beberapa tanaman obat bekerja secara sinergis untuk mengurangi peradangan sendi kronis arthritis. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antiarthtritis kombinasi rimpang jahe merah dan Acalypha seluruh tanaman ekstrak etanol pada lengkap Freund adjuvant diinduksi arthtritis. Arthritis ajuvan diinduksi pada tikus pada hari 0. Sembilan hari setelah inokulasi, hewan-hewan itu dipilih dan didistribusikan ke dalam 5 kelompok. Satu kelompok diberi 0,5% larutan CMC sebagai kelompok kendaraan yang diobati, yang lain diberi ekstrak jahe merah (280 mg/kg bb), ekstrak Acalypha (200 mg/kg) kombinasi merah jahe dan ekstrak Acalypha (140 mg/kg bb : 100 mg/kg bb), dan triamcinolone (0,3 mg/kg bb) secara lisan. Tingkat peradangan dievaluasi oleh belakang sweeling kaki, didukung oleh histopatologi sendi pergelangan kaki. Hasil penelitian menunjukkan bahwa sediaan oral ekstrak Acalypha, ekstrak jahe merah, serta kombinasi mengurangi mereka belakang kaki bengkak, sebanding dengan yang dari triamsinolon. Studi Histopatologi mengungkapkan penurunan yang signifikan dalam infiltrasi mononuklear dan meningkatkan ruang sendi pergelangan kaki. Kombinasi rimpang jahe merah dan ekstrak acalypha menunjukkan efek perlindungan terhadap pembantu diinduksi arthritis


Keywords


rimpang jahe merah, Acalypha, Freund adjuvant lengkap, antiarthritis, histopatologi.

References


Bansod MS.,Kagathara VG.,Pujari RR.,Patel VB.

and Ardeshna HH. 2011. Therapeutic effect of a poly-herbal preparation on

ad juvant induced arthritis in Wistar rats. International Journal of Pharmacy and Pharmaceutical Sciences, 3: 186-192.

Bendele A., McComb J., Gould T., McAbee T.,

Sennello G., Chlipala E., Guy M. 1999. Animal models of arthritis: relevance to human disease. Toxicol. Pathol., 27: 134-142.

Bendele AM. 2001. Animal model of rheumato

darthritis. The Journal of Musculoskel Neuron Interact, 1(4): 377-385.

Funk JL., Frye JB., Oyarzo JN., Timmermann

BN. 2009. Comparative effects of two gingerol-containing Zingiber officinale extracts on experimental rheumatoid arthritis. J Nat Prod., 72:403-407.

Ghildiyal S., Gautam MK., Joshi VK. and

Goel RK. 2013. Anti-inflammatory activity of two classical formulations of Laghupanchamula in rats. J Ayurveda Integr Med., 4:23-7.

Krishna VL., Chitra V. and Reddy JS. 2011. Anti

arthritic activity of whole plant Acalypha indica on Type II collagen Induced Arthritis in Wistar Rats. International Journal of Pharmacy and Pharmaceutical Sciences, 3(5): 99-102

Long L., Soeken K. and Ernst E. 2001. Herbal

medicine for treatment of osteoarthritis: a systematic review. Rheumatology, 40: 779-793.

Patwardhan SK., Bodas KS. and Gundewar SS.

Coping with arthritis using safer herbal options. International J. of Pharmacy and Pharmaceutical Sciences, 2(1): 1-11

Ram HN., Sriwastava NK. Makhija IK. and

Shreehara CS. 2012. Anti-inflammatory activity of ajmodadi churna extract againstacute inflammation in rats. J Ayurveda Integr Med., 3:33-7.

Rehman R.,Akram M.,Akhtar N.,Jabeen Q.,

Saeed T., Shah SM., Ahmed K., Shaheen G. and Asif HM. 2011. Zingiber officinale Roscoe (pharmacological activity). Journal of Medicinal Plants Research, 5(3): 344-348.

Shen CL., Hong KJ. and Kim SW. 2003.

Effects of ginger (Zingiber officinale Rosc.) on decreasing the production of inflammatory mediators in sow osteoarthrotic cartilage explants. J. Med. Food, 6: 323-328.


Full Text: PDF

Refbacks

  • There are currently no refbacks.



Jurnal Tumbuhan Obat Indonesia (Journal of  Indonesian Medicinal Plant, p-ISSN : 1979-892X, e-ISSN : 2354-8797) is published by Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional (B2P2TOOT) Tawangmangu.

Indexed by:

Lisensi Creative Commons
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Visitor number: View My Stats