Hypoglycaemic activity of aqueous extract of leafs of Strobilanthes crispa L. in male Wistar rats using glucose tolerance test method

Afifah B Sutjiatmo, Sri Wahyuningsih, Suci Nar Vikasari, Sri Wijayanti

Hypoglycaemic activity of aqueous extract of leafs of Strobilanthes crispa L. in male Wistar rats using glucose tolerance test method

Abstract


ABSTRACT

Extract of has been used traditionally to treat diabetes mellitus and gallstones. The objective of this study is to test hypoglycemic effect of aqueous extract of leafs of S. crispa in rats using glucose tolerance test method. Aqueous extract of leafs of S. crispa L. at doses 150 mg/kg bw and 300 mg/kg bw were orally administered in male Wistar rat. Blood glucose rate was analysed every 60 minutes over 3 hours. As conclusion, aqueous extract of leafs of S. crispa at dose 150 mg/kg bw gave similar effect with chlorpropamid at dose 9 mg/kg bw.

ABSTRAK

Daun Strobilanthes crispa L. digunakan dalam pengobatan tradisional untuk mengatasi diabetes dan batu ginjal. Penelitian ini bertujuan untuk mengetahui efek hipoglikemik ekstrak air daun Strobilanthes crispa L. pada tikus betina galur Wistar dengan metode toleransi glukosa. Ekstrak dosis 150 dan 300 mg/kg bb masing-masing diberikan p.o pada tikus betina. Analisa peningkatan glukosa darah dilakukan setiap 60 menit selama 3 jam. Kesimpulan penelitian ini, ekstrak air daun Strobilanthes crispa L. dosis 150 mg/kg bb memiliki efek yang setara dengan klorpropamid dosis 9 mg/kg bb.


Keywords


Key words: Strobilanthes crispa L., hypoglycaemic, blood glucose, aqueous extract, chlorpropamid

References


REFERENCES

Dipiro JT., Talbert, RL., Yee GC., Matzke GR., Wells BG., Posey LM. 2008. Pharmacotherapy, A Pathophysiologic Approach, McGraw Hill Co., 7th ed., p. 1206.

Departemen Kesehatan Republik Indonesia. 1977. Materia Medika Indonesia, jilid 1, Departemen Kesehatan RI, Jakarta, 95.

Fransworth, NR. 1966. Biological and Phytochemical Screening of Plants. J. Pharm Science, 55: 245-257.

Hutapea, JR. 1991. Inventaris Tanaman Obat Indonesia (I), jilid 1, Departemen Kesehatan dan Kesejahteraan Sosial RI, Badan Penelitian dan Pengembangan Kesehatan, 223-234.


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Jurnal Tumbuhan Obat Indonesia (Journal of  Indonesian Medicinal Plant, p-ISSN : 1979-892X, e-ISSN : 2354-8797) is published by Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional (B2P2TOOT) Tawangmangu.

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