STRUCTURE OF STEROIDS IN Stelechocarpus burahol Hook f. & Thomson STEM BARK Struktur steroid dalam kulit batang Stelechocarpus burahol Hook f. & Thomson

Clara Sunardi

STRUCTURE OF STEROIDS IN Stelechocarpus burahol Hook f. & Thomson STEM BARK Struktur steroid dalam kulit batang Stelechocarpus burahol Hook f. & Thomson

Abstract


ABSTRACTNatural steroids can be used for pharmaceutical production. Especially served as starting material for their partialsynthesis of sex hormones, including the oral contraceptives. In this research, steroid was obtained as byproductsfound during isolation and identification of cytotoxic compounds from Stelechocarpus burahol Hook f.& Thomson stem bark. The steroid mixture appears as white powder, consist of 3 steroid components: Δ5-ergostenol,stigmasterol, and β-sitosterol. Structure elucidation has been done using GC-MS and 1H-NMR spectroscopic.The result was compared with literature standard

 

ABSTRAKSteroids alam digunakan dalam berbagai produk farmasi, terutama sebagai material awal untuk sintesis parsialhormon reproduksi termasuk oral kontrasepsi. Dalam penelitian ini steroid ditemukan sebagai produksampingan dari proses isolasi dan identifikasi senyawa sitotoksik kulit batang Stelechocarpus burahol HookF & Thomson. Campuran steroid berupa serbuk putih yang terdiri dari 3 komponen :Δ5-ergostenol, stigmasterol,dan β-sitosterol. Elusidasi struktur menggunakan GCMS dan 1H-NMR. Hasilnya dibandingkan denganliteratur standar.Kata kunci: steroid, Stelechocarpus burahol


Keywords


steroid, Stelechocarpus burahol

References


LITERATURES

Clara, SAS. 2003. Isolasi dan Identifikasi

Senyawa Sitotoksik Kulit Batang Burahol,

Stelechocarpus burahol (Blume) Hook f. &

Thomson terhadap Sel Leukemia L1210,

Disertasi, Institut Teknologi Bandung, 25

Oktober.

The Merck Index. 2001. An Encyclopedia of

Chemicals, Drugs, and Biologicals, Thirteenth

Edition, Merck & CO., Inc., Whitehouse

Station, NJ., 8627, 8893


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Jurnal Tumbuhan Obat Indonesia (Journal of  Indonesian Medicinal Plant, p-ISSN : 1979-892X, e-ISSN : 2354-8797) is published by Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional (B2P2TOOT) Tawangmangu.

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