ANTIDIABETIC PROPERTIES OF ANDROGRAPHIS PANICULATA NEES AND EUGENIA POLYANTHA WIGHT LEAVES IN WISTAR RATS BY ORAL GLUCOSE TOLERANCE TEST

Ratna Megawati Widharna, Ferawati Ferawati, Lucia Hendriati, Andrianta Surjadhana, Arijanto Jonosewojo, Elisabeth Catherina Widjajakusuma

ANTIDIABETIC PROPERTIES OF ANDROGRAPHIS PANICULATA NEES AND EUGENIA POLYANTHA WIGHT LEAVES IN WISTAR RATS BY ORAL GLUCOSE TOLERANCE TEST

Abstract


Ekstrak etanol dan ekstrak air Andrographis paniculata Ness dan ekstrak etanol Eugenia polyantha Wight digunakan untuk evaluasi efek hipoglikemia pada tikus Wistar albino yang sehat dengan tes toleransi glukosa. Ekstrak etanol Eugenia polyantha (200 mg/kg bb) dan ekstrak air Andrographis paniculata (200 mg/kg bb) keduanya menunjukkan peningkatan kadar glukosa dalam darah secara signifikan pada T30 dan T60 (T30 = 30 menit setelah diisi glukosa atau 60 menit setelah pemberian obat dan T60 = 60 menit setelah diisi glukosa atau 90 menit setelah pemberian obat). Sedangkan ekstrak etanol Andrographis paniculata (200 mg/kg bb) menunjukkan peningkatan kadar glukosa dalam darah secara signifikan hingga level T90. Hal tersebut menunjukkan ekstrak air Andrographis paniculata (200 mg/kg bb) lebih cepat untuk menurunkan kadar glukosa dalam darah daripada ekstrak etanol pada dosis pemberian obat yang sama. Ekstrak air Andrographis paniculata dan daun Eugenia polyantha perlu diteliti lebih lanjut aktivitas menurunkan kadar glukosa dalam darah dan tidak menyebabkab hipoglikemia seperti pada glibenklamida.

Abstract

Ethanol and water extraet of Andrographis paniculata Nees, and ethanol extract of Eugenia polyantba Wight leaves were evaluated for their hypoglycemic effects in healthyalbino Wistar rats by oral glucose tolerance test. Both ethanol extract of Euginta polyantba (200 mg/kg bw) and water extract of Andrographis paniculata (200 mglkg bw) showed significant increased of blood glucose level at T30 and T60 (T30" 30 minutes after glucose loading or 60 minutes after drugs administration, T60 '" 60 minutes after glucose loading or 90 minutes after drugs administration). Meanwhile, ethanol extraet of Andrographis paniculata (200 mglkg bw) showed significant increased in blood glucose level up to T90. Therefore, water extract of Andrographis paniculata (200 mg/kg bb) was considered faster to lower blood glucose level than the ethanol extraet at the same dose of administration. Furthermore, water extract of Andrographis paniculata and Eugirua polyantba leaves could be selected for further research as they reduce the blood glucose level steadily and does not cause hypoglycemia such as in glibenclamide.


Keywords


Andrographis paniculata, Eugenia polyantha, glukosa darah

References


REFERENCES

Adedapo A., Obadan AY., and Ohore OG. 2007. Studies on the effects of the aqueous extract of the leaves of Andrographis paniculata in rats. International Symposium of Biology, Chemistry, Pharmacology and Clinical Studies of Asian Plants, Surabaya, Indonesia.

Ariyanti, R., Wahyuningtyas N., dan Wahyuni AS. 2007. Salam (Eugenia polyantha Wight) leaf infusa effect in reducing male mice uric acid level induced by potassium oxonate. Pharmacon, 8, 56–63.

Dai GF., Xu HW., Wang JF., Liu FW., and Liu HM. 2006. Studies on the novel α-glucosidase inhibitory activity and structure–activity

relationships for andrographolide analogues. Bioorganic & Medicinal Chemistry Letters, 16: 2710–2713.

Hendradjatin, AA. 2009. Efek anti bakteri infusa daun salam (Eugenia polyantha Wight) secara in vitro terhadap V. choleare dan E. coli enteropatogen. Majalah Kedokteran Bandung, 36.

Nugroho, YS. 2010. Pengaruh pemberian ekstrak daun salam (Eugenia polyantha) terhadap kadar gula darah tikus putih (Rattus Norvegicus) penderita hiperglikemia. (Skripsi) Univeristas Airlangga.

Lelono RAA., Tachibana S., Itoh K. 2009. In vitro Antioxidative activities and polyphenol content of Eugenia polyantha Wight grown in Indonesia. Pakistan Journal of Biological Sciences, 12: 1564-1570.


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Jurnal Tumbuhan Obat Indonesia (Journal of  Indonesian Medicinal Plant, p-ISSN : 1979-892X, e-ISSN : 2354-8797) is published by Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional (B2P2TOOT) Tawangmangu.

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