Evaluasi Keamanan dan Manfaat Ramuan Jamu untuk Hiperurisemia

Ulfa Fitriani, Danang Ardiyanto, Tofan Aries Mana

Abstract


Abstract
Hyperuricemia is a condition where there is an elevated blood uric acid level above normal range. Hyperuricemia occurs due to increased uric acid metabolism, decreased uric acid expenditure, or a combination of both. The Jamu formula containingPiper retrofractum, Plantago majorandApium
graveolens have the potential to overcome hyperuricemia. This study aims to evaluate the safety and efficacy of formula inhuman subjects with hyperuricemia. The method used was pre and posttest design for 28 days. Safety parameters were assessed by renal function (urea and creatinine) and liver function (SGOT and SGPT). The parameters of efficacy were measured by uric acid change (H0, H14, and H28), improvement of clinical symptoms and quality of life (SF-36). This study showed that kidney and liver function still in the normal rangeafter28 days of intervention. The levels of uric acid showed a significant decrease (p <0.05). Clinical symptoms of the subjectsimproved after 17 daysofintervention. SF-36
indicated significant improvement (p <0.05). It can be concluded that the formula was proved to be safe and effective for 28 daysof intervention.

Key words: hyperuricemia, jamu, safety, efficacy

Abstrak
Hiperurisemia adalah suatu keadaan dimana terjadi peningkatan kadar asam urat darah di atas rentang normal. Hiperurisemia terjadi karena adanya peningkatan metabolisme asam urat, penurunan pengeluaran
asam urat, atau gabungan keduanya. Ramuan jamu yang terdiri dari buah cabe jawa (Piper retrofractum), daun sendok (Plantago major) dan herba seledri (Apium graveolens) berpotensi dalam mengatasi hiperurisemia. Penelitian ini bertujuan untuk melakukan evaluasi keamanan dan manfaat ramuan jamudengan subjek manusia dengan hiperurisemia. Metode yang digunakan adalah quasi eksperimental pre and post test design selama 28 hari dengan 50 subjek. Parameter keamanan dinilai berdasarkan fungsi ginjal (ureum dan kreatinin) dan fungsi hati (SGOT dan SGPT). Parameter manfaat dilihat dari perubahan asam urat subjek (H0, H14, H28), perbaikan gejala klinis dan pengukuran kualitas hidup (SF-36). Fungsi ginjal dan hati subjek setelah intervensi dalam rentang nilai normal. Kadar asam urat menunjukkan penurunan yang signifikan (p<0,05). Gejala klinis subjek membaik setelah intervensi selama 17 hari.
Perubahan kualitas hidup subjek juga mengalami perbaikan yang signifikan (p<0,05). Dapat disimpulkan bahwa ramuan jamu terbukti aman dan bermanfaat dalam mengatasi hiperurisemia selama 28 hari.

Kata kunci: Hiperurisemia, jamu, keamanan, khasiat


Keywords


hiperurisemia, Jamu, keamanan, khasiat

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