Kadar Leptin sebagai Petanda Diabetes pada Individu dengan Diabetes dan Toleransi Glukosa Terganggu

Uly Alfi Nikmah, Frans Dany

Abstract


Abstract
Leptin is an adipocitokin hormone, produced by adipose tissue that is associated with the increasing of type 2 diabetic risk. Uncontrol impaired glucose tolerance (IGT)in a person has a high risk of being diabetics person. The aim of the research is to measure leptin level in an individu with diabetes mellitus (DM) and IGT in the year 2011 and 2013 and also to compare the leptin level with their lifestyle. Methods of the research are using ELISA technique and analyze the lifestyle based on the public health data. The results show that leptin level in the diabetics person is equivalent with impaired glucose tolerance person, and leptin level between groups is not significantly different in 2011 and 2013. The odds ratio of smoke behavior shows no correlation with leptin level, but the
body mass index (BMI)-risk on DM and IGT person shows 2.3 times than normal. Exercise habits on diabetic and IGT persons show that their leptin level is of 1.22 times lower, and the normal persons’ leptin level is of 1.5 times lower than untreated persons with exercise. The result proves that exercises slightly decrease leptin level and also decrease the diabetes risk.


Keywords: leptin level, type 2 diabetic, impaired glucose tolerance

Abstrak
Leptin merupakan hormon adipositokin yang dihasilkan oleh jaringan lemak tubuh yang dihubungkan dengan peningkatan risiko terjadinya diabetes tipe 2. Individu dengan toleransi glukosa terganggu memiliki kemungkinan besar akan berkembang menjadi diabetes tipe 2 jika tidak terkontrol. Penelitian ini bertujuan mengukur dan membandingkan kadar leptin pada individu dengan diabetes melitus dan toleransi glukosa terganggu (TGT) pada tahun 2011 dan 2013 serta membandingkannya
dengan gaya hidup. Metode yang digunakan adalah pemeriksaan kadar leptin di laboratorium dengan teknik ELISA dan dianalisis dengan gaya hidup yang dihubungkan data kesehatan masyarakatnya. Hasil penelitian menunjukkan kadar leptin individu dengan diabetes sebanding dengan individu dengan TGT dengan kadar leptin yang lebih tinggi dari normal, serta kadar leptin kedua kelompok tidak berbeda bermakna antara tahun 2011 dan 2013 karena tidak adanya intervensi antara tahun tersebut. Odds rasio pada kebiasaan merokok menunjukkan tidak mempengaruhi kadar leptin, sedangkan Indeks Massa Tubuh (IMT) berisiko pada individu DM dan TGT menunjukkan hasil 2,3x dari normal. Kebiasaan olahraga pada diabetes dan TGT memiliki kadar leptin 1,22x lebih rendah
dibanding yang tidak olahraga, sedangkan responden normal 1,5x lebih rendah. Hal ini membuktikan bahwa olah raga sedikit menurunkan risiko tingginya kadar leptin yang diiringi dengan menurunnya risiko terjadinya diabetes.

Kata kunci: kadar leptin, diabetes tipe 2, toleransi glukosa terganggu


Keywords


leptin level; type 2 diabetes; impaired glucose tolerance/prediabetes

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Buletin Penelitian Kesehatan (Bulletin of Health Research, p-ISSN: 0125-9695. e-ISSN: 2338-3453) is published by Badan Penelitian dan Pengembangan Kesehatan, Ministry of Health of Republic of Indonesia
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