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PENGARUH EKSTRAK ETANOL BIJI KLABET (Trigonella foenum- graecum L.) TERHADAP KADAR GULA DARAH TIKUS NIDDM

Lucie Widowati, Sumali Wiryowidagdo, Pudjiastuti Pudjiastuti

Abstract


Trigonella foenum-graecum L. (klabet) is one of the Indonesian medicinal plants and can be used to decrease glucose blood level on sufferer of diabetic. The effect of hypoglycemic of klabet seed extract on albino male rats has been investigated. Hyper­glycemic was induced by alloxan tetrahydrate 125 mg/kg body weight. The doses of the klabet extract were administered orally during 3 days and 7 days. Plasma glucose level was measured by Tinder method. Decrease percentage of plasma glucose level in gliclazide 1.4 mg/200g body weight, klabet seed extract 140 (DI), 280 (DII) and 560 (DIII) mg/200g body weight after 3 days of administration were 26.2, 17.97, 17.21, 14.17 respectively and decrease percentage after 7 days of administration were 42.74, 41.22, 42.86, 34.77 res­pectively. The effect of hypoglycemic was observed on 140 mg/200g body weight and 280 mg/200g body weight (p>0.05).


Keywords


Trigonella foenum-graecum L.; Klabet; Ethanol extract seed; Hypoglycemic

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Buletin Penelitian Kesehatan (Bulletin of Health Research, p-ISSN: 0125-9695. e-ISSN: 2338-3453) is published by Badan Penelitian dan Pengembangan Kesehatan, Ministry of Health of Republic of Indonesia
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